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Tropical Journal of Pharmaceutical Research

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Anticancer potentials of sinomenine from Sinomenium acutum: A mini-review

Shuang Yang, Lan-Yu Peng, Wei Peng, Cong Huang, Da-Neng Wei, Mao-Ting Mou, Fang Liang, Yong-Xiang Gao

Abstract


Sinomenine, an important isoquinoline from Sinomenium acutum (Menispermaceae), is currently considered as a reliable drug for treating various malignant cancers including breast cancer, colon cancer, lung cancer, liver cancer, gastric cancer, osteosarcoma cervical cancer, and esophageal cancer. The pharmacological mechanisms are probably related to induction of apoptosis and cell cycle arrest. This paper was aimed at reviewing the anticancer potential of sinomenine, which is expected to be beneficial in developing this compound as a candidate drug for cancer therapy.

Keywords: Sinomenine, Anticancer, Sinomenium acutum, Traditional Chinese Medicine



http://dx.doi.org/10.4314/tjpr.v17i12.30
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