Main Article Content

Formulation and development of a topical combination cream for arthritis management


Shafayat Hossain
Abdullah Shamim
Md Saifuzzaman
Md Attiquzzaman
Golam Hossain
Obayed Raihan

Abstract

Purpose: To design and prepare a non-prescription cream for cost-effective, potent, rapid and longlasting relief from arthritic pain.
Method: The cream was prepared by formulating the aqueous phase using glucosamine sulphate, potassium chloride and chondroitin sulphate sodium, and then pouring it into the oil phase under suitable conditions. The physicochemical and antimicrobial properties, in vitro and ex vivo drug release, and overall physical and chemical stability of the formulations were characterized.
Results: Sodium metabisulfite (0.5 %) and butylated hydroxyanisole (BHA) (0.01 %) showed a very strong synergistic effect on overall stability of the cream.
Conclusion: This study confirms that the formulated cream is potentially suitable for the management of arthritis pain in patients.


Keywords: Arthritis, Ex vivo drug release, Sodium metabisulfite, Butylated hydroxyanisole, Product stability


Journal Identifiers


eISSN: 1596-9827
print ISSN: 1596-5996