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Assessment of the relationship between depression and treatment compliance in chronically-ill patients in Jeddah, Saudi Arabia

Ameen Mosleh Almohammadi
Somayah Saeed Bawazeer
Joud Jamal Balkhair
Aroub Adel Rajab


Purpose: To find the relationship between depression, treatment adherence and lifestyle changes in
chronically-ill patients residing in Jeddah, Saudi Arabia.
Methods: A cross-sectional study was conducted. A self-administered questionnaire was used to
collect data from patients of multi-healthcare centers located in Jeddah. The questionnaire aimed to
collect the information regarding patients’ levels of medication compliance, patients’ capacity to cope
with the disease and adherence to medication, along with their depression level.
Results: Of the overall sample size of 439 patients, 43.1 % were suffering from hypertension, 37.8 %
were diabetic and 33.7 % had hyperlipidemia. Besides, total scores of Patient Health Questionnaire-9
(PHQ-9) showed that approximately 5 % patients were severely depressed, 8 % had moderately severe
depression, 27 % had moderate depression, and 60 % had mild depression. Compliance scale data
revealed that 38 % patients showed low compliance, 51 % showed partial compliance, and 11 %
showed high compliance. Also, a significant inverse relationship between depression and compliance
scales (rs = -0.221, p = 0.004) was observed.
Conclusion: The results show an inverse association between depression and medication adherence
in patients with chronic disease in Jeddah. Therefore, clinicians are advised to assess the level of
depression in chronically-ill patients in order to improve their adherence to medicine.
Keywords: Chronic illness, Depression, Medication adherence, Treatment compliance