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A comparative study of the analgesic effects of sevoflurane and propofol in children following otolaryngology surgical procedures: A pilot study

Yanwu Wang
Fan Yao
Yulong Lin
Shugen Xiao


Purpose: To determine the analgesic effects of sevoflurane (Sev) and propofol (Pro) in children who
underwent otolaryngology surgical procedures, and their post-operative conditions.
Methods: A total of 62 (ASA I or ASA II) pre-medicated children who were about to undergo
otolaryngology surgical procedures were chosen and divided equally into Sev and Pro groups, with 31
patients per group. During the surgical procedure, Sev was administered via a mask, while Pro was
given i.v. Each anesthesia was followed with fentanyl administration.
Results: Pain scores such as verbal rating scale (VRS) and visual analogue scale (VAS) were slightly
lower in Sev group than in Pro group. However, post-operative conditions such as emergence delirium
(ED) and emergence agitation (EA) were significantly elevated in Sev group, when compared to Pro
group (p < 0.05). In addition, patients in Sev group had higher levels of hemodynamic parameters
(blood pressure), and much higher number of adverse events than those in Pro group. Thus, the overall
satisfaction score and recovery characteristics, i.e., hospitalization time and recovery were slightly
better in Pro-anesthetized children than in those given Sev.
Conclusion: These results suggest that except for pain score, Pro-anesthetized children fared better in
terms of speedy recovery and reduced adverse effects than those given Pro. Thus, Pro may be
recommended as general anaesthetic for children undergoing otolaryngology surgical procedures.
Keywords: Sevoflurane, Propofol, Pain score, Emergence agitation, Otolaryngology