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Prospects for intranasal drug delivery systems with <i>Ginkgo biloba</i> in the treatment of cerebral circulatory disorders

N.D. Bunyatyan
E.V. Kovtun
I.A. Samylina
E.F. Stepanova
Yu V. Olefir
L.A. Korol
A.B. Prokofiev
V.A. Evteev
D.O. Bokov


Purpose: To analyze the range of currently available nasal medicines, and to study extant information on the use of Ginkgo biloba herbal complexes for the treatment of cerebral circulatory disorders of different etiologies. The study dwelt on the features and prospects of intranasal drug administration. Currently, intranasal administration is used primarily for the treatment of local symptoms. However, it has a much higher potential: the mucous membrane of the nasal cavity offers an opportunity for noninvasive treatment using systemic administration.

Methods: The study involved the analysis of materials from information-retrieval systems, library databases, patent databases, and scientific information repositories such as e-Library. PubMed, Scopus, Google Scholar, as well as materials from the websites of manufacturers of herbal medicinal products and other herbal substances.

Results: Herbal medicinal products have great potential in terms of intranasal administration. This is especially true of herbal medicines obtained through extraction of leaves of Ginkgo biloba, which have a broad spectrum of action, i.e., anti-aggregatory, venotonic, nootropic, anti-hypoxic, antioxidant, antiinflammatory, membrane-stabilizing, and capillary-protective effects. The range of Ginkgo biloba-based medicines calls for expansion, and this testifies to a good potential of these products in terms of further research and use. The analysis of literature and technical information showed the existence of a wide range of nasal medicines currently in use. However, only few drugs are used for the treatment of cerebrovascular diseases. Furthermore, there are no herbal medicines among these drugs, despite obvious advantages of herbal products such as ease of use, high bioavailability, and systemic action potential.

Conclusion: The current status of research on nasal dosage forms of Ginkgo biloba herbal complexes warrants further development involving biopharmaceutical and pharmacological studies.

Journal Identifiers

eISSN: 1596-9827
print ISSN: 1596-5996