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Published:
Jul 19, 2021Keywords:
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Main Article Content
Recent perspectives on chemosensitizing effects of Astragalus membranaceus-derived components: A mini review
Abstract
The dried root of Astragalus membranaceus (Fisch.) Bge (AM) is commonly used in herbal medicine in Korea, Japan and China. The traditional use of AM is to invigorate the Qi as a potential treatment for fatigue, loss of appetite, diarrhea, and anemia. Recent studies have expanded current understanding of AM as an antidiabetic, antioxidant, anti-inflammatory, antihyperlipidemic and anticancer agent. Active compounds derived from AM, including polysaccharides, saponins and flavonoids, appear to act as potent chemosensitizers when combined with conventional anticancer agents. Chemosensitizers represent a promising approach for enhancing anticancer efficacy and reversing multidrug resistance. This review highlights the chemosensitizing activity and related molecular mechanisms of components isolated from AM.
