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Published:
Aug 10, 2022DOI:
10.4314/tjpr.v21i6.8Keywords:
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Main Article Content
<i>Lactobacillus Kimchicus</i>-fermented <i>Ficus caria</i> fruits and leaves extract as an inhibitor of α-MSH-mediated melanogenesis in B16F10 mouse melanoma cells
Abstract
Purpose: To explore the anti-melanogenetic effects of Lactobacillus Kimchicus-fermented Ficus caria fruits and leaves extracts (KFFE) in B16F10 mouse melanoma cells.
Methods: The anti-melanogenetic effects of Lactobacillus Kimchicus-fermented Ficus caria fruit and leaf extracts (KFFE) were assessed using melanin contents assay and tyrosinase expression and activity assay in α-MSH-treated B16F10 mouse melanoma cells.
Results: The KFFE reduced α-MSH-mediated melanin synthesis in B16F10 mouse melanoma cells, while the tyrosinase mRNA expression was down-regulated by KFFE in B16F10 mouse melanoma cells (p < 0.05). Furthermore, cellular tyrosinase activity was downregulated by KFFE in B16F10 mouse melanoma cells (p < 0.05).
Conclusion: KFFE functions to repress melanin synthesis and thus, can potentially be used as a cosmetic ingredient.
