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Published:
Jul 12, 2023Keywords:
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Main Article Content
Effect of levothyroxine sodium on preterm infants with hypothyroidism
Abstract
Purpose: To investigate the effect of levothyroxine sodium on preterm infants with hypothyroidism.
Methods: The study involved a total of 96 preterm infants with hypothyroidism who were admitted to the Shengli Oilfield Central Hospital, Dongying, from January 2020 to October 2021. These patients were divided randomly into a study group and control group with 48 patients in each group. The control group was given routine treatment, while study group received levothyroxine sodium tablets orally. Growth and development (height, and weight), mental development index (MDI score), psychomotor development index (PDI score), and thyroxine levels (thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4)) between both groups were recorded.
Results: After treatment, thyroxine indices in both groups were significantly improved, but the indices in study group were better than in control group (p < 0.05). Growth, mental and psychomotor development indices in the improved groups were improved, but the improvements in the study group were significantly better than in control group (p < 0.05). The overall response rate (ORR) in the study group (93.75 %) was significantly higher than in the control group (77.08 %; p < 0.05).
Conclusion: Levothyroxine sodium improves growth, mental and psychomotor development, and thyroxine level in preterm infants with hypothyroidism. This protocol will benefit from further large-scale investigation prior to application in clinical practice.
