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Published:
Apr 10, 2026DOI:
10.4314/tjpr.v25i3.1Keywords:
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Main Article Content
Preparation of Moringa oleifera gel for the treatment of second-degree burns in a diabetic rat model
Abstract
Purpose: To determine the effectiveness of Moringa oleifera leaf extract in a gel preparation for treating second-degree burns in diabetic rat models. Method: The animals were divided into five groups labelled placebo, Bioplacenton®, and test preparations of 5, 10, and 15 % concentrations, respectively. Diabetes mellitus was first induced using intraperitoneal streptozotocin at a dose of 30 mg/kg BW and confirmed on the 3rd day; then, second-degree burns were made on the backs of the animals. The 96 % ethanolic extract of mature Moringa oleifera was made into a gel. The placebo, Bioplacenton and gel preparations were then applied to the wounds of their labelled models. Wound healing was assessed through the healing rate based on the percentage decrease in wound diameter on the day of observation compared to the wound diameter the day after the wound was made. Results: There were statistically significant differences in wound healing rates among the groups (Bioplacenton, Placebo, 5, 10, and 15 %) treated with Moringa leaf gel on the 3rd, 6th, and 9th day (p < 0.05). There was no significant difference in healing rate among the 5 groups on the 12th and 14th day (p > 0.05). The average healing of second-degree burns occurred on the 14th day. Conclusion: Moringa leaves in gel preparations at 5, 10, and 15 % accelerate the healing process of second-degree burns in diabetic rat model.
