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Published:
Jul 11, 2026DOI:
10.4314/tjpr.v25i6.5Keywords:
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Main Article Content
In vitro assessment of the antiproliferative effects of Iraqi Euryops pectinatus ethyl acetate extract on MDA-MB-231 breast cancer cells
Abstract
Purpose: To investigate the antiproliferative activity of ethyl acetate extract of Iraqi Euryops pectinatus on MDA-MB-231 human breast cancer cells.
Methods: The dried plant material was extracted by maceration with solvents of increasing polarity. The ethyl acetate extract was subjected to RP-HPLC for phytochemical profiling. The antiproliferative activity of the extract was assessed by MTT assay on MDA-MB-231 breast cancer cells.
Results: Several phenolic and flavonoid compounds such as quercetin, apigenin, rutin, rosmarinic acid, caffeic acid and naringenin were present. Cytotoxic activity of the ethyl acetate extract was concentration-dependent against MDA-MB-231 cells with an IC50 value of approximately 2023 µg/mL. Cell viability decreased significantly with increasing extract concentrations, indicating moderate antiproliferative activity (p < 0.05). Observed activity may be associated with combined or synergistic effects of the identified phenolic and flavonoid constituents.
Conclusion: Euryops pectinatus significantly exhibits cytotoxic activity against MDA-MB-231 breast cancer cells in a concentration-dependent manner, attributed to the synergistic effects of the phytoconstituents.
