Phytochemical Screening and In-vivo Antipyretic Activity of the Methanol Leaf-Extract of Bombax Malabaricum DC (Bombacaceae)
AbstractPurpose: To investigate the antipyretic activity of the methanol extract of Bombax malabaricum leaves (MEBM) in rats.
Methods: Baker’s yeast was used to induce fever in Wistar rats which were divided into four groups. The animal groups were thereafter administered MEBM (200 mg/kg), MEBM (400 mg/kg), paracetamol (reference standard, 150 mg/kg) and 1 % Tween 80 (control), respectively. The body temperature of the rats was measured rectally over a period of 8 h. MEBM was also phytochemically screened for alkaloids, steroids, carbohydrates, tannins, fixed oils, proteins, triterpenoids, deoxy-sugar, flavonoid, cyanogenetic and coumarin glycosides.
Results: MEBM (200 mg/kg and 400 mg/kg) significantly reduced yeast-induced pyrexia (p < 0.05, p <0.01, respectively). Phytochemical tests showed the presence of steroids, carbohydrates, tannins, triterpenoids, deoxy-sugars, flavonoids and coumarin glycosides.
Conclusion: The methanol extract of Bombax malabaricum leaves possesses significant antipyretic activity.
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.