Article Sidebar
Keywords:
Article Details
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.
Main Article Content
Effect of <i>Manasamitra vatakam</i>, an Ayurvedic Formulation, on Aluminium-Induced Neurotoxicity in Rats
Abstract
Purpose: To investigate the effect of Manasamitra vatakam (MMV), an Ayurvedic formulation, on aluminium (Al)-induced neurotoxicity in rats.
Methods: Wistar rats were selected for the present study and were divided into four groups of six animals each. Group I (control) received tap water while group II received aluminium chloride (AlCl3, 100 mg/kg/day). Group III was treated with concurrently Al chloride (100 mg/kg/day) and MMV drug (100 mg/kg /day). Group IV were administered MMV (100 mg/kg/day) for 90 days. Behavioral tests were performed on the rats during the experiment. At the end of the experiment various biochemical,
neurochemical and histopathological histopathological was assessments were also carried out on the blood and brain of the rats.
Results: Following MMV treatment, there was a significant recovery in the performance of the radial maze and muscle grip strength of the rats, as well as the levels of deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and acetylcholinestrase (AChE) in different parts of the rat’s brain. The neuroprotective efficacy of MMV was supported by histopathological observations. Furthermore, MMV afforded protection against oxidative damage in the rats.
Conclusion: MMV prevents Al-induced toxicity in peripheral as well as in central nervous systems of rats. Therefore, further studies are required to ascertain its usefulness in humans.
Keywords: Rat brain, Aluminium chloride, Behavioral studies, Neurotoxicity, Manasamitra vatakam.
