Tropical Journal of Pharmaceutical Research

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Investigation of Association between Slime Production by Candida Spp and Susceptibility to Fluconazole and Voriconazole

B Kaskatepe, S Yildiz


Purpose: To determine the susceptibilities of fluconazole and voriconazole based on slime production by Candida spp.
Methods: Candida strains (115) isolated in the period between January 2011 and January 2012 were included in this study. Conventional methods were used for the identification. Candida albicans and non-C. albicans isolates were tested for slime production with modified tube adherence test and antifungal resistance with disk diffusion method.
Results: Slime positivity was 31.3 % in all Candida species. Slime positivity in non-C.albicans isolates (44.89 %) was higher than in C. albicans species (21.21 %). All C. albicans isolates were sensitive to fluconazole and voriconazole. The highest resistance to fluconazole (40 %) and voriconazole (5%) was by C. glabrata strains.
Conclusion: Species definition and determination of antifungal susceptibility patterns are advised for the proper management and treatment of patients.

Keywords: Candida, Fluconazole, Voriconazole, Antifungal susceptibility, Slime
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