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Investigation of the Antiasthmatic Properties of Ethanol Extract of Callophyllis japonica in Mice


WS Park
KS Lee
JH Chun
SH Urm
DS Lee
DY Lee
SG Park
SK Seo
SJ Heo
ZJ Qian
WK Jung
IW Choi

Abstract

Purpose: To determine whether an ethanol extract from Callophyllis japonica (C. japonica) could attenuate indices of airway inflammation in a murine model of ovalbumin (OVA)-induced asthma.
Methods: The free radical scavenging activity of the C. japonica ethanol extracts (CJE) were investigated using an electron spin resonance (ESR) system. To make develop animal model of asthma, mice were sensitized and challenged with OVA.
Results: CJE exhibited considerable scavenging activity of 71.08 ± 0.73, 79.11 ± 6.04%, 75.95 ± 7.01%, and 48.56 ± 5.96% of DPPH, alkyl, superoxide, and hydroxyl radicals, respectively. The successive intraperitoneal administration of CJE reduced the number of eosinophils in bronchoalveolar lavage (BAL) fluid, development of airway hyperresponsiveness (AHR), an increase in pulmonary Th2 cytokines, and allergen-specific immunoglobulin E (IgE).
Conclusion: Administration of CJE markedly alleviates all indices of airway inflammation. This study provides evidence that CJE plays a critical role in the amelioration of the pathogenetic process of allergic asthma in mice.

Keywords: Asthma, Phenolic contents, Free radical scavenging, Airway hyper-responsiveness, Cytokines, Immunoglobulin E


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eISSN: 1596-9827
print ISSN: 1596-5996