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Published:
May 24, 2005Keywords:
Steroidal Indoxyl Anti-Inflammatory Antidiarrhoeal
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Kamau, F., Kibwage, I., Guantai, A., Muriuki, G., & Munenge, R. (2005). Anti-Inflammatory and Anti-Diarrhoeal Activities of a Steroidal Indoxyl. East and Central African Journal of Pharmaceutical Sciences, 6(2), 26–29. https://doi.org/10.4314/ecajps.v6i2.9695
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Anti-Inflammatory and Anti-Diarrhoeal Activities of a Steroidal Indoxyl
Abstract
The anti-inflammatory and antidiarrhoeal activities of 3β-Hydroxy-16, 17-seco-16-nor-5-androsten-15-(2-indoxyliden)-17-oic acid (I) are reported. After intraperitoneal administration, compound (I) gave an ED50 of 9.5 mg/kg using the carrageenan induced rat paw oedema anti-inflammatory assay method. Indomethacin had an ED50 of 5.8 mg/kg in this assay. Compound (I) and indomethacin caused comparable and dose-dependent varying degrees of delay in diarrhoea and also significantly reduced net colonic water flux into the colon of rats induced by castor oil.
Key words: Steroidal Indoxyl, Anti-Inflammatory, Antidiarrhoeal.
East and Central African Journal of Pharmaceutical Sciences Vol.6(2) 2003: 26-29
Key words: Steroidal Indoxyl, Anti-Inflammatory, Antidiarrhoeal.
East and Central African Journal of Pharmaceutical Sciences Vol.6(2) 2003: 26-29
