Clinical characteristics and results of radiotherapy in localized prostate cancers: an analytical case series at the Alassane Ouattara National Center of Medical Oncology and Radiotherapy, Cote d’Ivoire

Abstract

Context and objectives. Radiotherapy is commonly used in localized prostate cancer, but its practice is recent in Côte d'Ivoire. The objectives of the present study were to describe the clinical profile and evaluate the results of radiotherapy for localized prostate cancer. Methods. This was a historical follow-up study of prostate cancer patients treated with radiotherapy. Parameters of interest included clinical, therapeutic and evolutionary data. The primary endpoint was survival (time to death), which was described by the Kaplan Meier method. Results. One hundred and twenty patients (mean age 65.1%, high-risk cancer 74.2%) were included. All treatments were performed in 3D technique with a total dose varying between 66 and 74Gy according to conventional fractionation. All patients received hormone therapy. With a median follow-up of 44.7 months, overall and biochemical relapse-free survival rates were 89.1% and 82.8% at 3 years, and 79.9% and 67% at 5 years, respectively. In the bivariate analysis, Gleason scores 6 and 7 were associated with better PFSb. Late toxicities such as grade I or II cystitis and/or rectitis were observed in 37.5%. Conclusion. Prostate cancer is diagnosed most often at an advanced stage. Radiotherapy in combination with hormonal therapy has provided good disease control and tolerance in treated patients.