Identifying plant extracts as sources of antimalarial compounds needs to be addressed as numerous studies screen extracts without the means of eliminating extracts that are merely cytotoxic. Fifty-nine organic solvent extracts from South African plants were screened for antiplasmodial activity using the [3H]-hypoxanthine incorporation assay against the chloroquine-resistant Plasmodium falciparum. Variable antiplasmodial activity and toxicity was observed. Extracts form Combretum erythrophyllum
and Crinum bulbispermum, had IC50 values 1 mg/ml with the ethyl acetate extracts of C. bulbispermum roots and bulbs having values comparable to chloroquine (0.04 mg/ml). Nine extracts had
toxicity indexes 100. Lycorine, isolated from C. bulbispermum was as active as chloroquine (IC50 of 0.03 mg/ml) and had a favourable security index.