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African Journal of Biomedical Research

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Neuropharmacological activities of Ficus platyphylla stem bark in mice

OK Wakeel, PI Aziba, RB Ashorobi, S Umukoro, AO Aderibigbe, EO Awe

Abstract


Methanol Extract Ficus platyphylla stem bark in dosages (17, 40 and 75, 150mg/kg) was found to produce a profound decrease in exploratory activity in mice, the extract indicated peripheral and central analgesic effects as shown by significant inhibition of acetic acid -induced writhing, and delayed onset in leptazol induced-convulsion (seizures) in mice
respectively. It also decreases the rate of leptazol induced mortality in mice. The totality of these effects showed that the extract possesses depressant action on the central nervous system.



http://dx.doi.org/10.4314/ajbr.v7i2.54073
AJOL African Journals Online