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African Journal of Biomedical Research

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Anti-Inflammatory and Anti-Nociceptive Effects of Ethanolic Extract of Mammea Africana Stembark In Rodents

JE Okokon, EE Umoh, U Umoh

Abstract


The ethanolic stembark extract of M .africana (30-90 mg/kg) was investigated for pharmacological properties against egg white albumin - induced inflammation, Chemical as well as thermal- induced pain as well as yeast induced pyresis in rats. The extract demonstrated a dose – dependent anti- inflammatory , antinociceptive and antipyretic activities. These activities were comparable to that of ASA (100mg/kg). The stembark extract possess anti inflammatory , analgesic and antipyretic properties, which can be exploited in health care.

Keywords: M. africana, anti inflammatory, analgesic, antipyretic.




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