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Hypoglycaemic and Antioxidative Properties of Freeze-Dried Garcinia Kola Seeds in Type 2 Diabetics and Non-Diabetics with Chronic Foot/Leg Ulcer in Ibadan, Nigeria: A case-control clinical study

Elizabeth Bosede Bolajoko
Augustine Anayochukwu Onyeaghala
Olubayo Michael Akinosun
Alfred Francis Attah
Olufemi Joseph Adewumi
Adefunke Temiloa Adeoti
Ayodele Olukayode Iyun
Adesoji Adedipe Fasanmade
Jones Olanrewaju Moody
Aye Aye Khine


Introduction: The antidiabetic and antioxidative properties of Garcinia kola (GK) seed extracts have been well documented in animal studies; however, data on freeze-dried powder of GK seeds (FDGK) in humans are scarce. This study investigated the effect of 8-weeks supplementation of FDGK on glycaemic control and oxidative stress levels in Type 2 diabetics with or without foot/leg ulcer and compared with non-diabetics with or without chronic foot/leg ulcer in Ibadan, Nigeria.

Materials and Methods: Thirty diabetics with foot/leg ulcer (DFU), 30 diabetics without ulcer (T2DM), 30 non-diabetics with chronic foot/leg ulcer (NDCU) and 30 non-diabetics without ulcer (NDC) were divided into: subgroup-1 (250mgGK); subgroup-2 (500mgGK); subgroup-3 (No-supplementation). Plasma glucose (FPG), glycated haemoglobin-A1c (HbA1c), total plasma peroxides (TPP), total antioxidant status (TAS), oxidative stress index (OSI), antioxidant-micronutrients were determined in fasting blood samples. Wounds were clinically assessed and rated using modified ABDEFS.

Results: All participants supplemented with 250mgGK or 500mgGK for 8 weeks showed decreases in TPP and OSI with improvement in wound healing, increases in TAS and antioxidant-micronutrients (p<0.05). In addition, significant decreases in FPG were observed in DFU and T2DM supplemented with 250mgGK, and also in NDC supplemented with 500mgGK. In non-supplemented subgroups, increases in TPP and OSI with decreases in TAS and antioxidant-micronutrients (p<0.05) were observed.

Conclusion: Supplementation with Garcinia kola could be used as an adjunct for prevention and treatment of diabetes mellitus complicated with or without foot/leg ulcer

Recommendations: Caution must be taken when used as prophylactic in non-diabetics to prevent occurrence of hypoglycaemia.

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eISSN: 1022-9272