Antioxidant activity of Piper caninum and Cyclooxygenase-2 inhibition by methoxylated flavones.

  • MH Nadri
  • MA Naser
  • RM Zukifli
  • II Muhamad
  • F Ahmad
  • WMNHW Salleh
  • HM Sirat
Keywords: Piper caninum, antioxidant, cyclooxygenase-2.

Abstract

Background: This study investigated on antioxidant activity of Piper caninum and cyclooxygenase-2 inhibition by methoxylated flavones.
Materials and methods: The present study was carried out to quantify the total phenolic content and free radical scavenging activities of the crude extracts by Folin-Ciocalteu and 1,1-diphenyl-2-picrylhydrazyl free radical scavenging assay respectively.
Results: Methanolic extracts of Piper caninum exhibited the highest total phenolic content and free radical scavenging activities. All the pure compounds possessed significant cyclooxygenase-2 inhibition at physiological concentrations.
Conclusion: Based on in vitro and molecular docking, we therefore suggest that Piper caninum methoxylated flavones are potent inhibitors of cyclooxygenase-2 at physiological concentrations

Key words: Piper caninum; antioxidant; cyclooxygenase-2.

List of abbreviations: COX-2, cyclooxygenase-2; DPPH, 2,2-diphenyl- 1-picrylhydrazyl; PGE2, prostaglandin E2.

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eISSN: 0189-6016