Study of urinary interferon gamma-induced protein 10 (IP-10) and urinary soluble CD 25 (sCD25) as markers of lupus nephritis and their relation to histological class

  • Montasser Mohamed Hussein Zeid
  • Nahed Mohamed Baddour
  • Dalia Abd El-Moaty El-Neily
  • Heba Selim Elshair
  • Mohamed Mamdouh
Keywords: Lupus nephritis, Urinary, IP-10, CD25

Abstract

Objective: To study the role of urinary interferon gamma-induced protein 10 (IP-10) and urinary soluble CD 25 (sCD 25) as diagnostic and prognostic markers of lupus nephritis (LN) and their relation to the LN class in renal biopsy.

Subjects and methods: This study included 45 lupus patients fulfilling the Systemic Lupus International Collaborating Clinics (SLICC) classification criteria: 25 patients with active LN during activity and during follow up (3 months later) as [group A] and 20 patients without any signs of activity [group B]. (20) age and sex matched healthy subjects were enrolled as control group [group C]. Urine samples were collected at baseline and at follow up. Urinary IP-10 and sCD25 were measured by ELISA.

Results: Urinary IP-10 and sCD25 levels were higher in group A compared to groups B and C (P < 0.001 for both). In patients with active nephritis, urinary IP-10 and sCD25 correlated positively with serum creatinine (P < 0.001 for both), proteinuria (p = 0.010; p = 0.007), anti ds-DNA (p = 0.002; p < 0.001), SLEDAI
score (global) (P < 0.001 for both), and renal SLEDAI score (p = 0.002; p < 0.001) respectively. The urinary IP-10 and sCD25 levels were highest in patients with class (IV) LN and lowest in class (II) patients with a statistically significant difference. In patients achieving remission with treatment, both markers decreased significantly.

Conclusion: Urinary IP-10 and sCD25 are potential biomarkers for early recognition and follow up of LN.

Keywords: Lupus nephritis, Urinary, IP-10, CD25

Published
2019-01-22
Section
Articles

Journal Identifiers


eISSN: 2090-2948
print ISSN: 1110-0834