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Lipid Profile and Foetal Outcome in Obese Pregnant Females
Abstract
Objective: to compare lipid profile and foetal outcome in obese pregnant females to non obese women delivered in Alexandria.
Material and methods: The study is a case control study of women registered at El-Shatby Maternity University Hospital at the time of delivery in the period between June 2009 and June 2010. The cases were 50 pregnant obese women (BMI> 30Kg/ m2) aged 20-30 years. The controls were 50 normal pre-pregnancy weight women with
(BMI 18.5 – 24.9 Kg/ m2) matched with cases as regards age and gestational age. Data were gathered from women who delivered in addition to their caring obstetricians involved as well as reviewing the medical records. Laboratory investigations included assessment of lipid profile (serum cholesterol, and serum triglycerides) at the time of delivery. Also, leptin hormone was measured in serum of patients using DRG Leptin (Sandwich) ELISA (EIA-2395) USA.
Results: Caesarean section rate was significantly higher among obese women (82% versus 30%; P<0.001).
The mean serum leptin concentration was significantly higher in obese women (BMI>30 kg/m2)
than normal weight controls (p= 0.013). Neonates born to obese had a statistically significant increased
birth weight than infants of normal weight participants (P=0.0001). Additionally, neonates born to
obese women had an increased risk of admission to Neonatal Intensive Care Unit OR (4.1), 95% (CI) 1.2 -2.4, p<0.001.
Conclusion: Obesity is associated with increased adverse maternal and perinatal complications.
Material and methods: The study is a case control study of women registered at El-Shatby Maternity University Hospital at the time of delivery in the period between June 2009 and June 2010. The cases were 50 pregnant obese women (BMI> 30Kg/ m2) aged 20-30 years. The controls were 50 normal pre-pregnancy weight women with
(BMI 18.5 – 24.9 Kg/ m2) matched with cases as regards age and gestational age. Data were gathered from women who delivered in addition to their caring obstetricians involved as well as reviewing the medical records. Laboratory investigations included assessment of lipid profile (serum cholesterol, and serum triglycerides) at the time of delivery. Also, leptin hormone was measured in serum of patients using DRG Leptin (Sandwich) ELISA (EIA-2395) USA.
Results: Caesarean section rate was significantly higher among obese women (82% versus 30%; P<0.001).
The mean serum leptin concentration was significantly higher in obese women (BMI>30 kg/m2)
than normal weight controls (p= 0.013). Neonates born to obese had a statistically significant increased
birth weight than infants of normal weight participants (P=0.0001). Additionally, neonates born to
obese women had an increased risk of admission to Neonatal Intensive Care Unit OR (4.1), 95% (CI) 1.2 -2.4, p<0.001.
Conclusion: Obesity is associated with increased adverse maternal and perinatal complications.
