Central nervous system depressant effect of the fruits of Piper guineense

  • Felicia E. Williams
  • Olusegun S. Adedeji
  • Julius O. Aiyedun
  • Hope Obianwu
Keywords: Piper guineense, fruits, glycosidic constituents, central nervous system, depressant

Abstract

The central nervous system depressant effect of the butanol extract of the fruits of Piper guineense was pharmacologically screened by measuring the prolongation of barbiturate sleeping time. Nine rats (n=9) were used and assigned into three groups, with each group comprising of three rats (n=3). Group A served as the Control, while Groups B and C served as tests. Thiopentone sodium (40 mg/kg body weight) was administered subcutaneously to the rats in Group A, 2 mg/kg of the butanolic extract of the fruits of Piper guineense was administered subcutaneously to the rats in Test Group B, 30 minutes before administering same dose of thiopentone sodium, while rats in Group C received 4 mg/kg of the butanolic extract 30 minutes before administering same dose of thiopentone sodium. The sleeping time was recorded. Student-t-test at 5% significance level was used to analyze the results obtained. The mean barbiturate sleeping time prolongation of 53.67 minutes was produced by 2 mg/kg of the extract while a dose of 4 mg/kg produced mean barbiturate sleeping time prolongation of 103.67 minutes. This study suggests that the fruits of Piper guineense have central nervous system depressant effect.

Keywords: Piper guineense, fruits, glycosidic constituents, central nervous system, depressant

Biokemistri 28(1): 34–37

Author Biographies

Felicia E. Williams
Department of Clinical Pharmacy and Pharmacy Practice, University of Ilorin, Ilorin, Nigeria
Olusegun S. Adedeji
Department of Animal Production and Biotechnology, Ladoke Akintola University of Technology, Ogbomosho, Nigeria
Julius O. Aiyedun
Department of Veterinary Public Health and Preventive Medicine, University of Ilorin, Ilorin, Nigeria
Hope Obianwu
Department of Pharmacology and Toxicology, University of Benin, Benin City, Nigeria
Published
2020-02-03
Section
Articles

Journal Identifiers


eISSN: 0795-8080