Assessement of fibrinogen level and thrombin time in pregnant women in Sokoto

Abstract

Background: Pregnancy is the fertilization and development of one or more offspring, known as an embryo or foetus in a woman's uterus.
Aim: of this study was to determine to what extent pregnancy affects fibrinogen concentration and thrombin time when compared with a control group of non-pregnant women.
Methods: Fibrinogen concentration (FC) was determined using Clauss technique and Thrombin time was determined using two stage method.
Results: The FC high among the pregnant subjects (2.79 ± 0.78 g/L) compared to the non-pregnant controls (1.37 ± 0.16 g/L). The thrombin time of pregnant women was shorter (14.35 ± 1.69 seconds) compared to that of non-pregnant women (21.84 ±0.77seconds).The mean of FC and TT of the pregnant subjects was compared based on trimester, the mean fibrinogen concentration was significantly higher (p=0.05) among pregnant women in the third trimester (3.31± 0.56 g/L) compared to the second (2.42±0.57 g/L) and first trimester (2.19± 0.71 g/L) respectively.
Conclusion: our result showed that pregnancy causes changes in haemostatic parameters fibrinogen and thrombin.