Effects of Cataranthus roseus on Electrolyte Derangement Induced by Chlorpropamide (Diabinese)R on Normoglycemic Albino Wistar Rat

  • MU Eteng
  • HA Ibekwe
  • AD Essien
  • HP Onyeama
Keywords: <i>Cataranthus roseus</i>, Electrolyte derangement, Diabinese, Normoglycemic

Abstract



This study was designed to evaluate the efficacy (or otherwise) of Cataranthus roseus extract in ameliorating electrolyte imbalance following treatment with anti-diabetic drug chlorpropamide (Diabinese)R. A total of 32 rats of mixed sexes were randomly assigned into 4 treatment groups of 8 rats each. Group A (control) received placebo (0.14ml of 30% ethanol)/ kg body weight of rat. Group B received Diabinese in a dose of 1.6mg/kg body weight of rat while group C received 400mg /kg body weight of Cataranthus roseus (C. roseus) extract. Group D received Diabinese in a dose of 1.6mg/kg body weight plus 400mg/kg body weight C. roseus extract. The above dosages were administered twice daily via orogastric intubation in a 12 hour cycle. The administration was terminated at the end of 14 days, animal sacrificed, serum collected and electrolyte (Na+, K+ and CL-) profile assayed. The result obtained showed no-significant (P>0.05) decrease in serum concentration of chloride ion in Group B-D relative to control. There is however, a significant (P<0.05) reduction in serum potassium ion and sodium which is well pronounced in serum of rats treated with Diabinese and mild in group C treated with C. roseus. However, a combined treatment of C. roseus with Diabinese significantly (P<0.05) elevated serum sodium ion concentration relative to control than Diabinese treated group alone. This implies a restoration of the seemingly hyponatremia associated with Diabinese therapy.

Keywords: Cataranthus roseus, Electrolyte derangement, Diabinese, Normoglycemic

Bio-Research Vol. 6 (2) 2008: pp. 364-366
Published
2009-01-06
Section
Articles

Journal Identifiers


eISSN: 2705-3822
print ISSN: 1596-7409