The effect of cosolvents and surfactants on the aqueous solubility of Irbesartan
AbstractIt was considered an interest to enhance the aqueous solubility of irbesartan. To accomplish this objective, the solubilization of irbesartan by cosolvency and micellization was investigated. It was found that all the cosolvents (ethanol, glycerol, propylene glycol) and surfactants (sodium lauryl sulfate,
polysorbate-80) increased the solubility of irbesartan. Sodium lauryl sulfate was observed to be the most effective of the solubilizing agents used. The increase in aqueous solubility of irbesartan at the maximum concentration studied was in the following order: sodium lauryl sulfate > polysorbate-80 > ethanol > propylene glycol > glycerol.
Copyright: Creative Commons Attribution CC.
This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials. View License Deed | View Legal Code Authors can also self-archive their manuscripts immediately and enable public access from their institution's repository. This is the final corrected version that has been accepted for publication and which typically includes author-incorporated changes suggested during submission, peer review and in editor-author communications.