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Low dose oral administration of monosodium glutamate in male albino rats may be nephroprotective

ACC Egbuonu
O Obidoa
CA Ezeokonkwo
LU Ezeanyika
PM Ejikeme


The speculation that low dose intake of monosodium glutamate over time may be toxic warranted the present study. The aim was to investigate the effect of the administration of monosodium glutamate at a low concentration on the functional capacity of the kidney. Thus, monosodium glutamate at a dose of 5 mg/kg of body weight was administered to adult male albino rats by oral intubation. Treatment was daily for 28 days. The monosodium glutamate treatment significantly (p < 0.05) decreased the serum sodium ion concentration by 11.38 % and the water intake by 9.39 %, but had no apparent change in the serum potassium ion concentration (change, 0.00 %). The treatment increased (p < 0.05) the serum urea and creatinine concentration by 12.80 % and 107.81 % respectively. Therefore, treating rats with monosodium glutamate at a low concentration (5 mg/kg of body weight) could be nephroprotective, but with possible significant dehydration. The health implications of the results are highlighted in the discussion.