Low dose oral administration of monosodium glutamate in male albino rats may be nephroprotective
Keywords:
Monosodium glutamate, Urea, Creatinine, Sodium ion, Potassium ion, Water intake
Abstract
The speculation that low dose intake of monosodium glutamate over time may be toxic warranted the present study. The aim was to investigate the effect of the administration of monosodium glutamate at a low concentration on the functional capacity of the kidney. Thus, monosodium glutamate at a dose of 5 mg/kg of body weight was administered to adult male albino rats by oral intubation. Treatment was daily for 28 days. The monosodium glutamate treatment significantly (p < 0.05) decreased the serum sodium ion concentration by 11.38 % and the water intake by 9.39 %, but had no apparent change in the serum potassium ion concentration (change, 0.00 %). The treatment increased (p < 0.05) the serum urea and creatinine concentration by 12.80 % and 107.81 % respectively. Therefore, treating rats with monosodium glutamate at a low concentration (5 mg/kg of body weight) could be nephroprotective, but with possible significant dehydration. The health implications of the results are highlighted in the discussion.
Issue
Section
Articles
Copyright: Creative Commons Attribution CC.
This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials. View License Deed | View Legal Code Authors can also self-archive their manuscripts immediately and enable public access from their institution's repository. This is the final corrected version that has been accepted for publication and which typically includes author-incorporated changes suggested during submission, peer review and in editor-author communications.
