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Clinical study of the role of Procalcitonin and some biochemical parameters in patients with Lymphoma in Thi-Qar Province - Iraq
Abstract
Objective: Lymphoma is a type of cancer that starts in the immune system's lymphocytes, which fight infections. The spleen, thymus, bone marrow, lymph nodes, and other organs contain these cells. When lymphoma occurs, lymphocytes alter and proliferate uncontrollably. This study is one of the initial Iraqi efforts to investigate the serum Procalcitonin, TNF-α, IL-6, and Zinc levels in Lymphoma patients and compare the values with those of healthy controls.
Methods: This study was a case-control study of 43 patients with Lymphoma and 37 controls recruited at the Oncology centre, referring hospitals, private clinic and laboratories in Thi-Qar, province of Iraq. Smokers, alcoholics, and recent antibiotic users were excluded from the study to mitigate the confounding effect. Serum Procalcitonin, TNF-α, IL-6, and Zinc levels were assessed in all participants.
Result: The participants' ages ranged from 17 to 32 years. The mean levels of serum procalcitonin (p<0.0001), TNF-α (p<0.0001), and IL-6 (p<0.0001) levels of patients with Lymphoma were significantly higher than those of the control group. However, serum zinc level was lower among the cases than the control group (p<0.0001).
Conclusion: In patients with solid tumours, the combined measurement of PCT and IL-6 may serve as indicators of the progression of neoplastic diseases. Serum TNF-α and IL-6 levels can serve as prognostic indicators for the assessment of tumour immune status in Lymphoma. Poor nutritional status at initial diagnosis may have affected serum zinc levels in lymphoma patients.
