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Synthesis, characterization and antibacterial activity of 4- (phenyl sulfonyl) aminoacetophenone

A.O. Ijeomah, G.O. Agwaza, M.N. Tseeka


The synthesis of 4-(phenylsulfonyl) aminoacetophenone which involve the base catalyzed sulfonylation of 4- aminoacetophenone using benzene sulfonyl chloride is reported. The chemical structure of the synthesized compound was elucidated using FT-IR, UV, 1HNMR and 13CNMR characterization. The compound was screened for its antibacterial activities against gram positive and gram negative bacterial strains namely: Staphylococcus aureus, Escherichia coli, Salmonella typhi and Pseudomonas aeruginosa. The antibacterial activity was determined by measuring inhibition zone diameter. It was found that the compound has potent antibacterial activity against Staphylococcus areus and Pseudomonas aeruginosa with IZD of 18 mm and 17mm respectively.

Keywords: Antibacterial, Characterization, sulphonamides, Synthesis, 4- phenylsulphnyl) minoacetophenone

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