Neuropharmacological Evaluation of Aridanin, a Glycoside Isolated from Tetrapleura tetraptera Fruit

  • AO Aderibigbe
  • EO Iwalewa
  • SK Adesina
  • OE Ukponmwan
  • AO Adebanjo
Keywords: Aridanin, central activities, sedation, <i>Tetrapleura tetraptera</i> fruit


The neuropharmacological effects of Aridanin Ð an N-acetylated glycoside isolated from Tetrapleura tetraptera fruit was examined for locomotory, exploratory, stereotyped behaviours and hexobarbitone-induced sleeping time (HIST) in mice. Aridanin (15- and 30 mg/kg i.p) produced a dose-dependent inhibition of novelty-induced rearing, grooming, body scratching and exploratory behaviour. It also potentiated the hexobarbitone-induced sleeping time (HIST), but did not change the stereotyped behaviour induced by apomorphine. These effects of aridanin suggest that it has a strong central depressant action which may be sedative in nature but lack psychopharmacological activities

Keywords: Aridanin; central activities, sedation, Tetrapleura tetraptera fruit

Discovery and Innovation Vol. 19 (3) 2007: pp. 177-181

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eISSN: 1015-079X