Neuropharmacological Evaluation of Aridanin, a Glycoside Isolated from Tetrapleura tetraptera Fruit

Abstract

The neuropharmacological effects of Aridanin Ð an N-acetylated glycoside isolated from Tetrapleura tetraptera fruit was examined for locomotory, exploratory, stereotyped behaviours and hexobarbitone-induced sleeping time (HIST) in mice. Aridanin (15- and 30 mg/kg i.p) produced a dose-dependent inhibition of novelty-induced rearing, grooming, body scratching and exploratory behaviour. It also potentiated the hexobarbitone-induced sleeping time (HIST), but did not change the stereotyped behaviour induced by apomorphine. These effects of aridanin suggest that it has a strong central depressant action which may be sedative in nature but lack psychopharmacological activities

Keywords: Aridanin; central activities, sedation, Tetrapleura tetraptera fruit

Discovery and Innovation Vol. 19 (3) 2007: pp. 177-181