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Female Genital Mutilation (FGM) is a serious and disturbing health concern across the world. This study aims to examine and explore factors that could prevent or promote efforts targeted toward the elimination of FGM in all the places where this harmful practice persists. In the last three decades, several attempts have been put in place by several international and national health-related organizations (such as UNICEF. WHO, USAID, and federal ministries of health) to end the practice. Apart from the normal community-based sensitization and stakeholders' engagement on the harmful effects of FGM, many countries like Egypt, Ghana, Senegal, and Uganda have instituted bans on female genital mutilation by criminalizing the practice, as part of the efforts to eliminate this inhumane practice. Though the general knowledge, attitudes, and awareness about the practice have changed over time, there is evidence of collective abandonment of FGM in some local communities. The prevalence of FGM is falling slowly in most countries and the practice has sluggishly declined in some places like Nigeria, Ethiopia, Cote d’Ivoire, and Kenya. Nonetheless, the current underlying population growth in most of the affected countries has constituted an additional challenge toward a timely eradication of female genital mutilation. Hence, a comprehensive understanding of effective strategies that could speedily eliminate female genital mutilation becomes a top priority to achieve the United Nations Sustainable Development Goal of eliminating FGM by the year 2030. Therefore, through an in-depth integrative review, this study explores some factors that are considered capable of facilitating the timely eradication of FGM. The findings of this study show that culture, religion, illiteracy, and sexual control are the key factors that promote the practice of FGM in most societies where the practice persists. The study, therefore, recommends key strategies that could speedily facilitate the effective elimination of FGM. It is also suggested that adequate attention should be given to the emerging female adolescents, who technically constitute the age group that is responsible for future reproduction and national population growth, and this developmental status places them in a crucial position that offers them a unique opportunity to diligently and collectively discontinue this evil practice in their communities.