Binding Properties Of A Polymeric Gum From <i>Cola accuminata</i>

Abstract

The binding properties of a polymeric gum obtained from the pods of Cola accuminata was studied. The tablets produced with the new gum showed good weight uniformity, friability and hardness profiles. However all the tablets produced with 1 % w/w binder; Sodium carboxyl methyl cellulose (SCMC) and Cola accuminata failed the hardness test. Hardness increased while friability decreased as tablet binder concentration increased. However, the tablets produced with Cola accuminata gum had long disintegration times similar to the tablets produced with SCMC. Only the tablets produced with low binder concentrations of Cola accuminata and SCMC (1 – 2 % w/w) passed the disintegration time test. Moreover at 1-2 % w/w binder concentrations, tablets produced with Cola accuminata recorded higher drug release rates than the tablets containing SCMC. However at 4-6 % w/w binder concentrations, it showed drug release rates comparable with the tablets formulated with the standard binder SCMC.

KEY WORDS: Cola accuminata, binding property, disintegration time, Dissolution rate.

Global Journal of Pure and Applied Sciences Vol.11(2) 2005: 233-236