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May 17, 2005Keywords:
Hyperlipidaemia Dyslipidaemia Chronic Renal Failure
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Serum Lipids In Pre Dialysis Chronic Renal Failure Patients In Jos University Teaching Hospital, Nigeria
Abstract
A prospective study of serum lipids in pre dialysis chronic renal failure (CRF) patients in the Jos university teaching hospital over a twelve month period undertaken to determine the pattern of lipid abnormalities associated with this disease.
Lipids were measured in the fasting state using standard methods in 67 patients with CRF and 50 healthy controls. The means of total cholesterol and triglyceride were similar in both groups. The mean HDL cholesterol was significantly lower in the study group compared to controls; being 1.72+ 1.34 mmol/L and 4.21+ 1.89 mmol/L respectively (df= 1, F= 83.78, p < 0.001), while LDL cholesterol was significantly higher in the study group compared to controls (2.90+ 1.56 mmol/L vs. 1.87+ 1.00 mmol/L; df= 1, F= 16.99, p<0.001). Similarly, the mean LDL/HDL cholesterol, an index of atherogenicity, was significantly higher in the study group compared to controls (3.12+ 3.18 vs. 1.61+ 1.92; df=1, F= 8.85, p<0.001).
Serum lipid abnormalities are common in patients with CRF hence increasing the risk for the development of coronary heart disease in them. The management of such patients should also include treatments aimed at correcting lipid abnormalities.
KEY WORDS: Hyperlipidaemia, Dyslipidaemia, Chronic Renal Failure
Highland Medical Research Journal Vol.1(3) 2003: 13-17
Lipids were measured in the fasting state using standard methods in 67 patients with CRF and 50 healthy controls. The means of total cholesterol and triglyceride were similar in both groups. The mean HDL cholesterol was significantly lower in the study group compared to controls; being 1.72+ 1.34 mmol/L and 4.21+ 1.89 mmol/L respectively (df= 1, F= 83.78, p < 0.001), while LDL cholesterol was significantly higher in the study group compared to controls (2.90+ 1.56 mmol/L vs. 1.87+ 1.00 mmol/L; df= 1, F= 16.99, p<0.001). Similarly, the mean LDL/HDL cholesterol, an index of atherogenicity, was significantly higher in the study group compared to controls (3.12+ 3.18 vs. 1.61+ 1.92; df=1, F= 8.85, p<0.001).
Serum lipid abnormalities are common in patients with CRF hence increasing the risk for the development of coronary heart disease in them. The management of such patients should also include treatments aimed at correcting lipid abnormalities.
KEY WORDS: Hyperlipidaemia, Dyslipidaemia, Chronic Renal Failure
Highland Medical Research Journal Vol.1(3) 2003: 13-17
