Distribution Of Serum T3/T4 Quotient In Euthyroid Goitrous Subject In Nigeria- A Probable Biochemical Marker Of Goiter Endemia
AbstractObjective. To determine the relationship between the serum levels of (T4) thyroxin, (T3) Tri-iodothyronine, and (TSH) Thyrotropin versus the goiter size in an endemic euthyroid goitrous subject.
Materials and Methods. Serum levels of thyroxin (T4), Tri-iodothyronine(T3), and thyrotrophin (TSH) were determined by “ELISA” technique in 58 adult euthyroid goitrous subjects with various grades of endemic giotre, and in 42 adult normal subjects used as control.
Findings. The serum thyroxin (T4) levels were depressed to a low normal range in most of the subjects with advanced goitre, while Tri-iodothyronine (T3) levels were in the high normal to supra normal region.
Thyroid size was found to bear a negative correlation with serum Thyroxin (T4) levels levels(r = 0.6; p=0.05) and positive correlation with Tri-iodothyronine(T3) levels (r = 0.8; p=0.001), as well as with serum thyrotropin (TSH) concentration (r = 0.9; p-0.001). The serum T3/T4 ratio showed a strong positive correlation with the size of the enlarged thyroids in this group of patient, (r = 0.8; p=0.001).
Conclusion. The findings suggest that the serum T3/T4 ratio in the euthyroid goitrous subjects may probably be used as a valuable biochemical indicator in the epidemiological assessment of endemic goiytre in a population
Highland Medical Research Journal Vol.2(1) 2004: 17-21