PROMOTING ACCESS TO AFRICAN RESEARCH

International Journal of Biological and Chemical Sciences

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Doxycyclin induces p53 expression in SaOs (osteosarcoma) cell line

O Obasuyi

Abstract


The p53 tumour suppressor gene plays an important role in preventing cancer development. This study determined if p53 can be induced in osteosarcoma cell line upon treatment with Doxycyline. It was demonstrated that induction of p53 resulted in the inhibition of the cyclin E/CDK2 complexes by the activation of p21. This mechanism could potentially therefore represent an important component of the p53 tumor suppressor pathway.

Keywords: Tumor suppressor, oncogene, mdm2, cyclinE, apoptosis



http://dx.doi.org/10.4314/ijbcs.v9i1.37
AJOL African Journals Online