Doxycyclin induces p53 expression in SaOs (osteosarcoma) cell line
AbstractThe p53 tumour suppressor gene plays an important role in preventing cancer development. This study determined if p53 can be induced in osteosarcoma cell line upon treatment with Doxycyline. It was demonstrated that induction of p53 resulted in the inhibition of the cyclin E/CDK2 complexes by the activation of p21. This mechanism could potentially therefore represent an important component of the p53 tumor suppressor pathway.
Keywords: Tumor suppressor, oncogene, mdm2, cyclinE, apoptosis
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