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<i>In vivo</i>. hypolipidemic and hypoglycemic effects of aqueous extract of <i>Spondias mombin</i> leaves and detoxification of reactive oxygen species in alloxan-induced diabetic rats

Etah Etah Nkanu
Sikirullai Olatunde Jeje
Daniel Ewa Ikpi
Gabriel Otu Ujong


The effect of aqueous extract of Spondias mombin leaves extract on lipid peroxidation and antioxidant activity in alloxan induced diabetes was studied. Forty male albino Wistar rats (100-150 g body weight) were used. The rats were randomly selected into four groups containing 10 rats each. Group 1 was the control group and it was placed on normal rat chow. Group 2 was the Spondias mombin (spm) group placed on normal rat chow and given 250 mg/kg extract orally. Group 3 was the alloxan-induced diabetic (150 mg/kg) group (DM) and Group 4 was the diabetic group treated with 250 mg/kg extracts (Dm+spm). At the end of 30 days blood samples were collected by cardiac puncture and used for biochemical analysis. Results obtained revealed that blood glucose level in group 3 (Dm) was significantly higher (p<0.05) than control but the administration of Spondias mombin leaves extract significantly reduced the blood glucose level (p<0.05). Total cholesterol (TC), triglycerides (TG) and Low Density Lipoprotein (LDL) were significantly raised in the diabetic group while High Density Lipoprotein (HDL) was significantly reduced (p<0.05). Treatment with extract decreased TC, TG, LDL but significantly increased the HDL level (p<0.05). Lipid peroxidation was increased in the diabetic group and treatment with extract significantly reduced (p<0.05) the level of lipid peroxidation. Superoxide dismutase (SOD) and catalase (CAT) activities were decreased significantly in the diabetic group. Administration of extracts increased the antioxidant enzymes activities. The result suggests that aqueous extracts of Spondias mombin leaves possess hypoglycemic effects and improve lipid profile of diabetic rats. This effect may be secondary to its ability to reduce oxidative stress.

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Keywords: Diabetes, SOD, CAT, Lipid peroxidation, hypolipidemic, hypoglycemic, Spondias mombin