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International Journal of Biological and Chemical Sciences

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Structure-activity relationship of Schiff base derivatives of bis(aminophenyl)disulfide and p-vanillin as antimicrobial agents

Y Narain, S Jhaumeer-Laulloo, MG Bhowon

Abstract


A series of Schiff bases (1-9) were assayed for antibacterial (S. aureus, E. faecalis P. aeruginosa) and antifungal (C. albicans and A. niger) activities using disc diffusion method. Among the compounds tested [bis(p-methoxybenzaldimino)phenyldisulfide], 5 showed the most favourable antibacterial and [o,o'-(N,Ndipicolinyldene) diazadiphenyldisulfide], 6 antifungal activities with MICs of 1 mg/mL and 0.025 mg/mL against S. aureus and C. albicans respectively.

© 2010 International Formulae Group. All rights reserved.

Keywords: Antibacterial activity, antifungal, Schiff bases, disulfide.




http://dx.doi.org/10.4314/ijbcs.v4i1.54232
AJOL African Journals Online