Evaluation of drug Quality II: Determination of Amoxicillin concentration in proprietary capsules

  • AE Ejele
  • NU Anyawu
  • CI Anunuso

Abstract

The concentrations of amoxicillin in proprietary preparations of amoxicillin capsules, obtained in Nigeria, were determined using the titrimetric and UV-spectrophotometric methods. The result obtained showed that the concentration of all amoxicillin brands studied were close to each other and within the allowed pharmacopoeia specification for amoxicillin capsule of label strength value of 500 mg, which lies between 480-520 mg/cap, since data analysis showed that amoxicillin concentrations found in this study ranged from 483–520 mg/cap. Statistical analysis of data showed that there was no significant difference between the two methods used in this study and the amoxicillin samples studied were not significantly different from one another.

Keywords: Amoxicillin concentration, capsules, spectrophotometric/titrimetric methods

International Journal of Natural and Applied Sciences, 7(1): 109 - 114, 2011

Author Biographies

AE Ejele
Department of Chemistry, Federal University of Technology, PMB 1526, Owerri, Nigeria
NU Anyawu
Department of Chemistry, Federal University of Technology, PMB 1526, Owerri, Nigeria
CI Anunuso
Department of Chemistry, Federal University of Technology, PMB 1526, Owerri, Nigeria
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Articles

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eISSN: 0794-4713