The effect of <i>Mansoniaaltisma </i> on haematological parameters of rat

Abstract

The effect of ethamolic extract of Mansonia altisima on biochemical and haematological parameters were examined using the rat as animal model. Female wistar albino rats (105.00 ± 2.30g) were distributed into control and three test groups, with ten rats in each group. The test rats were treated orally by intubations with 0.5, 1.0 and 2.0 g of Mansonia extract per kilogram body weight of rat respectively (the doses were administered in 2.5 ml. of deionized water). Control rats were administered the same volume of deionized water (2.5 ml.). Rats administered the highest dose of the extract had a significantly higher (P<0.05) activity of plasma aminotransferases as compared to the other exposure groups. The plasma alkaline phosphatase activities of rats in the test groups were not significantly (P>0.05) different from each other, but were significantly (P<0.05) reduced as compared to controls. Also, no significant (P>0.05) difference was observed in plasma levels of creatinine and urea of rats in all exposure groups. The plasma uric acid concentration of the test groups were not significantly (P>0.05) different from each other, but were significantly (P<0.05) increased relative to control. A significant reduction in haemoglobin (Hb) and packed cell volume (PCV) was observed in rats administered the highest dose relative to control. There was a dose dependent increase in WBC count of rats administered the extract compared to control. The study suggests that ethanolic extract of Mansonia may be toxic to the liver at the highest dose administered.

Keywords: Mansonia, extract, toxicity, rats

Ife Journal of Science Vol. 8 (2) 2006: pp. 199-202