In order to determine the capacity building needs of farmers for safe agro-chemical use in Niger State, the study examined awareness of safety measures for agro-chemical usage, sources of awareness, practice of safety measures and training needs of farmers. One hundred and twenty farmers were randomly selected from three local government areas in the state. Validated interview schedule with reliability coefficient of 0.89 was used to collect data. Data collected were analyzed using descriptive statistics and correlation analysis. All the respondents were aware of wearing of protective clothing and avoiding drinking/eating during spraying, safety measure such as avoiding off label use (7.50%) had low awareness level. The major sources of awareness were friend/relatives (55.00%). The most widely practised safety measure was avoiding ingesting or inhaling chemicals (91.67%), while the least practised safety measure was avoiding off label use (2.50%).Reasons given for not practicing some safety measures include heaviness of protective clothing (17.50%) and unreadable nature of instruction labels (14.17%). Major areas of training needs of the respondents were application (61.67%) and handling (52.50%) of agro-chemicals. A positive significant correlation existed between education (r = 0.461), farming experience (r = 0.337), farm income (r = 0.307) and practice of safety measures. It was therefore recommended that enlightenment campaign should be carried out in the State to raise awareness level for safe use of agro-chemicals in the agricultural transformation programme, while the characters of the instruction labels should be boldly written to facilitate reading and practice of safety measures.