CO Ezugwu
National Center For Natural Products Research, Research Institute Of Pharmaceutical Sciences, University Of Mississippi, University, MS 38677, USA
B Erdal
National Center For Natural Products Research, Research Institute Of Pharmaceutical Sciences, University Of Mississippi, University, MS 38677, USA
D Chuck
National Center For Natural Products Research, Research Institute Of Pharmaceutical Sciences, University Of Mississippi, University, MS 38677, USA
AK Ikhlas
National Center For Natural Products Research, Research Institute Of Pharmaceutical Sciences, University Of Mississippi, University, MS 38677, USA and Department Of Pharmacognosy, School Of Pharmacy, University Of Mississippi, University, Ms 38677, USA
CO Okunji
International Centre For Ethnomedicine And Drug Development, Nsukka Nigeria; And Bioresources Development & Conservation Programme 11303 Amherst Avenue Suite # 2, Silver Spring, MD 20902 and Division Of Experimental Therapeutics, Walter Reed Army Institut
MS Brian
Division Of Experimental Therapeutics, Walter Reed Army Institute Of Research, Washington D, 20307-5100, USA
MM Iwu
International Centre For Ethnomedicine And Drug Development, Nsukka Nigeria; And Bioresources Development & Conservation Programme 11303 Amherst Avenue Suite # 2, Silver Spring, MD 20902 and Division Of Experimental Therapeutics, Walter Reed Army Institut
Abstract
7,8-dimethoxy-N-methylflindersine and 7,8-dimethoxy-3-(3-methylbut-2-enyl)-2-quinoline were isolated from the stem bark of Araliopsis tabouensis and their structures were assigned base on their 1H and 13C-NMR, DEPT 135, Gradient HMBC, G-HMQC and G-DQF-Cosy characteristics. The IC50 value in antimalarial bioassays vary from 1.8 to 4.7 μg/ml.
Key words: Araliopsis tabouensis, structural determination, antimalarial properties.
Journal of Pharmaceutical and Allied Sciences Vol.2(2) 2005: 214-218
