Hepatoprotective effect of Aqueous stem bark extract OF Boswellia Dalzielii against CCL4 induced Hepatotoxicity
AbstractThe dearth of remedies that have antioxidant properties that protect the liver and drugs that induce hepatotoxicity has prompted and accelerated research into plants used in folk medicines to treat liver diseases. This study was designed to evaluate the hepatoprotective/hepatocurative effect of the aqueous stem bark extract of Boswellia dalzielii against CCl4 induced hepatic damage in rats. The extract significantly reduced the AST, ALT, ALP, bilirubin and lipid peroxide levels which were elevated as a result of CCl4 administration. The reduced levels of antioxidants like glutathione and vitamins in CCl4 treated animals were significantly increased in extract treated animals. The result of the study showed that the extract can protect the integrity of the liver against toxins.
Keywords: hepatotoxicity, CCl4, drugs, Boswellia dalzielii
Journal of Pharmaceutical and Allied Sciences, Vol. 9 No. 2 (2012