Hepatoprotective effect of Aqueous stem bark extract OF Boswellia Dalzielii against CCL4 induced Hepatotoxicity

  • T Olatunji
  • BK Toge
  • M Lawal
  • MG Abubakar

Abstract

The dearth of remedies that have antioxidant properties that protect the liver and drugs that induce hepatotoxicity has prompted and accelerated research into plants used in folk medicines to treat liver diseases. This study was designed to evaluate the hepatoprotective/hepatocurative effect of the aqueous stem bark extract of Boswellia dalzielii against CCl4 induced hepatic damage in rats. The extract significantly reduced the AST, ALT, ALP, bilirubin and lipid peroxide levels which were elevated as a result of CCl4 administration. The reduced levels of antioxidants like glutathione and vitamins in CCl4 treated animals were significantly increased in extract treated animals. The result of the study showed that the extract can protect the integrity of the liver against toxins.

Keywords: hepatotoxicity, CCl4, drugs, Boswellia dalzielii

Journal of Pharmaceutical and Allied Sciences, Vol. 9 No. 2 (2012

Author Biographies

T Olatunji
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, P.M.B. 2346 Sokoto, Nigeria; Department of Pharmaceutics and Industrial Pharmacy, Delta State University, Abraka, Delta State
BK Toge
Department of Biochemistry, Usmanu Danfodiyo Univeristy, P.M.B. 2346 Sokoto, Nigeria
M Lawal
Department of Biochemistry, Usmanu Danfodiyo Univeristy, P.M.B. 2346 Sokoto, Nigeria
MG Abubakar
Department of Biochemistry, Usmanu Danfodiyo Univeristy, P.M.B. 2346 Sokoto, Nigeria
Published
2013-01-11
Section
Articles

Journal Identifiers


eISSN: 1596-8499