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In vitro evaluation of the quality control parameters of five brands of metronidazole tablets produced in Nigeria


KC Ugoeze
NE Vaikosen
N Nwachukwu
B Kabeletoge

Abstract

In this study, the quality control parameters of five brands of metronidazole tablets produced in Nigeria were assessed to ascertain their pharmacopeial compliance. The potency of the active drug content and other tablet properties were assessed using HPLC and the British Pharmacopeia methods respectively. Results show that the potency of all the samples investigated fell within limits of the British Pharmacopoeia specifications. The mechanical strength of the respective batches of tablets was within acceptable range. Disintegration of each sample occurred in less than 4 min. Over 80 % of drug content was released in 30 min for all the samples studied.

Keyords: Metronidazole, Tablet, Evaluation, Quality Control

Journal of Pharmaceutical and Allied Sciences, Vol. 9 No. 2 (2012)

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eISSN: 1596-8499