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Anti body responses in cattle and gui nea pigs vaccinated with montanide ISA 206 adjuvant formulation vaccine were observed. In this study the potency of the inactivated FMD vaccines types SAT! ( Nig 1/98) and SAT2 (Nig 2/97) formulated with montanide ISA 206 adjuvant was determined in guinea pigs and cattle by antibod) assay with CF and SN tests and by challenge. The antibody litres obtained with single and repeated inoculations gave good responses and protection from the challenge. The AT I I 46S (Nig. 1/98) antigen mai ntained a higher titre than SAT2 (Nig 2 '97) antigen. The formul ated vaccines were stable at 4oc throughout the duration of the study. It was also observed that animals with low and high antibody responses were all protected against FMD by vaccination that may not be, by strictly dependent on high antibod) production in the host. The information from this study showed that it might be possible to prepare and use combined or polyvalent montanide ISA 206 FMD vaccines for control of FMD in Nigerian Livestock.
Key words: Vaccine. SAT!. SATI , Montanide and antibod)