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Nigerian Journal of Biotechnology

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Quality evaluation of two FMD Vaccines Prepared from local Isolates of sero types SAT1 and SAT2 Antigens and Montanide ISA 206 Formulations

A Abegunde, AA Chukwuedo, NE Gomwalk

Abstract


Anti body responses in cattle and gui nea pigs vaccinated with montanide ISA 206 adjuvant formulation  vaccine were observed. In this study the potency of the inactivated FMD vaccines types SAT! ( Nig 1/98) and  SAT2 (Nig 2/97) formulated with montanide ISA 206 adjuvant was determined in guinea pigs and cattle by  antibod) assay with CF and SN tests and by challenge. The antibody litres obtained with single and repeated inoculations gave good responses and protection from the challenge. The AT I I 46S (Nig. 1/98) antigen mai  ntained a higher titre than SAT2 (Nig 2 '97) antigen. The formul ated vaccines were stable at 4oc throughout  the duration of the study. It was also observed that animals with low and high antibody responses were all  protected against FMD by vaccination that may not be, by strictly dependent on high antibod) production in the host. The information from this study showed that it might be possible to prepare and use combined or  polyvalent montanide ISA 206 FMD vaccines for control of FMD in Nigerian Livestock.

Key words: Vaccine. SAT!. SATI , Montanide and antibod)




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