Effect of white cabbage (Brassica oleracea) aqueous extract on oxidative stress in pre-diabetes – induced male albino rats
Background: Oxidative stress affects serum insulin and induces insulin resistance which results in pre-diabetic condition.
Objective: This research investigated the effect of white cabbage aqueous extract on the serum insulin, insulin resistance and oxidative stress in pre-diabetes induced male albino rats.
Methods: Prepared extracts from fresh and dried cabbage and thirty male albino rats grouped into six were used for the study. The positive control was fed regular diet, while negative control was fed high sucrose feed and the four test groups were fed high sucrose feed and extract. Different test group received 50 or 100 mg/kg of either of the extracts. The fasting blood sugar at baseline and at two weeks’ interval was recorded. At the end of the experiment at six weeks, the serum insulin, oral glucose tolerance test and liver oxidative stress were determined. Results were analyzed using Analysis of Variance (p < 0.05) followed by Duncan Multiple Range Tests for blood glucose and Graph pad prism 5.
Results: The extracts controlled the serum insulin and cell-resistance to insulin of the rats. There was a reduction in the malondialdehyde (MDA) and significant reduction in the activities ofsuperoxide dismutase (SOD) and catalase (CAT) by the extract while glutathione (GSH) increased. The MDA, SOD, CAT and GSH for the negative control group being 0.85 mg/ml, 0.8 mg/ml, 19.53 mg/ml and 5.18 μmol/ml while the highest for the test groups was; 0.84 mg/ml, 0.74 mg/ml, 17.37 mg/ml and 5.85 μmol/ml.
Conclusion: Cabbage had potential of reducing liver oxidative stress in pre-diabetic condition.
Keywords: Cabbage extract, blood sugar, hypoglycemic, oxidative stress
Manuscripts are accepted for publication with the understanding that no substantial part has been, or will be published elsewhere. By submitting a manuscript, the authors agree that the copyright is transferred to the publisher if and when the articles, including reprints, photographic reproduction and translation are published. Copyright owner is the Nutrition Society of Nigeria. An abstract at the beginning of an article may be reproduced without specific permission provided the original citation is provided. Statements made and opinions expressed in letters to the editor, editorials, presidential address, book reviews, and other special articles appearing in this journal are views of the author(s) and do not necessary reflect the position of the journal or the Nutrition Society of Nigeria.