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Research Journal of Health Sciences

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Diagnosis and Treatment of Thrombotic Thrombocytopenic Purpura

Mary Muoneke, Rasheed A Balogun

Abstract


Thrombotic thrombocytopenic purpura (TTP) is a rare clinical emergency that is characterized by features of microangiopathic hemolytic anemia and thrombocytopenia. The availability of effective therapy with therapeutic plasma exchange has decreased the mortality rate from 90 % to approximately 20%. The historical pentad of clinical features once thought to be needed to make the diagnosis include fever, anemia, renal failure, neurological findings and thrombocytopenia. Currently, clinical diagnosis is made by existence of thrombocytopenia and microangiopathic hemolytic anemia unexplained by other causes. The variety of clinical presentations and the lack of specific laboratory diagnostic criteria make the diagnosis of TTP highly dependent on a high index of clinical suspicion and can be easily missed. Early recognition and appropriate treatment with plasma exchange in clinical settings is very important and is frequently life saving. Current knowledge in the etiopathogenesis, epidemiology, trends in the diagnosis and treatment are reviewed herein.



AJOL African Journals Online