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Emerging genetic profile of type 2 diabetes mellitus patients and controls in south western Nigeria: Catalyst for sustainable development


C.A. Akinleye
P.B. Olaitan
C.O. Alebiosu
E.O. Asekun-Olarinmoye

Abstract

Background: In sub-Saharan Africa, Type 2 diabetes care is greatly hampered by huge financial burden causing poor accessibility to  healthcare. This study determined the genetic and environmental factors with potentials of attaining Goals 3 and 17 of the Sustainable Development Goals (SDGs) in Nigeria.


Methodology: This study was a case-control study. A multistage sampling technique was employed in the selection of 1500 patients with  T2DM and 1500 controls in South Western Nigeria. Biophysical measurements and Glycaemic biomarkers were assessed for all  respondents. Odds Ratio (OR) was determined with a level of significance was set at P<0.05


Results: The prevalence of Type 2 DM was 5%. However rural communities had older subjects with T2DM as compared with urban  communities P<0.01. Glycaemic biomarkers and biophysical profiles were age and sex-related p<0.05 in both rural and urban  communities. Transcription Factor 7 like 2 (TCF7L2) was found to be genetic marker of T2DM.


Conclusion: Transcription Factor 7 like 2  gene is a genetic marker of T2DM in Nigeria, which forms a framework for achieving goals 3 and 17 of the SDGs