Xylocaine^® 10% Pump Spray as topical anaesthetic for venepuncture pain

Abstract

Background: Cutaneous analgesia for venepuncture pain can be achieved using various topically applied local anaesthetic formulations. Xylocaine^®10% Pump Spray containing lignocaine hydrochloride and 95% ethanol is exclusively recommended for mucosal anaesthesia. However, this formulation is readily able to penetrate skin. This study investigated whether topical pretreatment with Xylocaine^® 10% Pump Spray could facilitate analgesia for venepuncture.

Methods: A single-centre, prospective, randomised, double-blind placebo-controlled trial was conducted. One hundred patients were enrolled. The control and intervention groups had 0.5 ml saline and 0.5 ml Xylocaine^®applied for 20 min to preselected venepuncture sites. Pain associated with an 18-gauge cannula venepuncture was rated on an 11-point Numerical Rating Scale. A two-point or 30% reduction in pain would be deemed clinically significant.

Results: Pain scores were lower (p= 0.001) in the Xylocaine^® (median 2; 95% CI 2–3) than the saline (median 4; 95% CI 3–5) group. Moderate-to-severe pain occurred in fewer Xylocaine^® (18%) than saline (42%) treated patients (relative risk 0.43, CI 0.22 to 0.48; NNT = 5).

Conclusion:Topical Xylocaine^®10% Pump Spray pre-treatment provided a time-effective method of reducing venepuncture associated pain.

Keywords:local anaesthesia, venepuncture pain, Xylocaine^® 10% Pump Spray