Article Sidebar
Published:
May 31, 2011Article Details
By submitting manuscripts to SAJAA, authors of original articles are assigning copyright to the SA Society of Anaesthesiologists. Authors may use their own work after publication without written permission, provided they acknowledge the original source. Individuals and academic institutions may freely copy and distribute articles published in SAJAA for educational and research purposes without obtaining permission.
Main Article Content
Local anaesthetic toxicity
Abstract
Local anaesthetic toxicity has been known since the introduction of local anaesthetic drugs into anaesthetic practice more than a hundred years ago. The aim of this review is to follow the history of the search for less toxic local anaesthetic drugs, to highlight molecular mechanisms thought to contribute to the clinical phenomenon of toxicity, and to finally discuss novel treatment strategies.
